Deepbiomics

Solution for advanced insights in health analysis

DeepBiomics represents an advanced approach to integrating and analyzing multiomics data through deep learning techniques. It focuses on utilizing sophisticated deep learning algorithms to handle complex and high-dimensional biological data from various sources, including genomics, transcriptomics, proteomics, and clinical phenotypes. This approach is designed to transform our understanding and management of health conditions

How does DeepBiomics work?

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Innovative graph and network-based representation

It uses advanced graph and network-based representations, to create clear and simple summaries of complex biological processes, proteins, or gene sequences by breaking them into manageable components. Its innovative design makes it an essential tool for biological research and precision healthcare, providing quick and accurate personalized insights.

Tailored Algorithms for a Holistic Understanding of Biological Systems

The DeepBiomics Platform functions as a quick computational engine, quickly evaluating complex biological data to improve tailored healthcare insights. Our advanced algorithms work with a wide range of data technologies, such as gene ontology, route databases, metagenomics, proteomics, epigenetics, 3D structural data of proteins, cellular imaging, and large text corpora.

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Increasing Intricacy while Maintaining Nuance

Our network and graph models capture the complex intricacies of biological systems, and ensure the precise delivery of personalized data. This commitment aligns with our mission to accelerate insights and drive innovative healthcare solutions.

Explore our research areas

DeepBiomics and Type 2 Diabetes

Deepbiomics intelligently links microbiome components to clinical pathways, pinpointing specific elements crucial for predicting T2D risk.

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AIBIOMICs and HORAIZON are joining forces

Type 2 diabetes (T2D) is a global health concern with high prevalence rates. To address this challenge, there is an urgent need for groundbreaking insights into the mechanisms and pathways influencing the onset and progression of T2D. Emerging research highlights the significant role of the gut microbiome in the development of this disease.

At DeepBiomics, our mission is to accelerate time-to-insight for personalized healthcare. The HORAIZON team is leveraging cutting-edge machine learning algorithms to analyze microbiome 16S/shotgun data from a diverse cohort of both healthy individuals and those with T2D.

Our analytical methods are designed to intelligently link microbiome components to clinical pathways, pinpointing specific elements crucial for predicting T2D risk. By connecting these components to distinct biological pathways and mechanisms, our approach not only serves as a predictive tool but also advances clinical research, potentially paving the way for new treatments and interventions.

Acknowledging the variability in T2D prevalence across different ethnic groups, we have developed ethnicity-specific predictive models. These specialized algorithms refine predictions by utilizing microbial biomarkers relevant to each ethnic group. In essence, HORAIZON is at the forefront of using advanced analytics to uncover new ways to understand and manage type 2 diabetes.

Cardiovascular Risk Prediction Through Advanced Proteomics

Our models excel at identifying a constellation of key biomarkers, significantly enhancing the prediction of cardiovascular events.

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‘GEEF om je buik’: Promoting health

In the rapidly evolving field of personalized medicine, accurately identifying individuals at high cardiovascular risk is more critical than ever. Traditional methods that rely on single biomarkers often fall short in providing effective risk estimates. These models excel at identifying a constellation of key biomarkers, significantly enhancing the prediction of cardiovascular events.

Our proteome-based risk model is trained on extensive datasets that cover a wide range of cases and conditions. It undergoes rigorous comparison with traditional risk factors in primary prevention settings and is validated on independent cohorts to ensure its reliability and applicability.

The predictive models we have created at HORAIZON not only introduce novel approaches but also significantly outperform conventional clinical risk factors. These advanced models are crucial tools in personalized medicine, improving both the accuracy and timeliness of cardiovascular risk predictions.

Epigenetics and inflammatory bowel disease​

Our models have identified specific epigenetic signatures at baseline, before treatment begins, that are linked to treatment responses,

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Epipredict: Treatment recommendation for Crohn’s disease patients

The introduction of biologics, such as anti-TNF agents, has significantly advanced the management of Crohn's disease. Despite this progress, about 70% of patients either do not respond to these medications or lose their responsiveness over time. Traditional treatment approaches often rely on a trial-and-error method due to the lack of reliable biomarkers to predict treatment outcomes. As a result, many patients endure months or even years of ineffective treatment, risking severe complications such as intestinal obstructions, perforations, multiple surgical resections, and even cancer.

To address this challenge, the HORAIZON team has developed innovative machine learning models that analyze epigenetic patterns in peripheral blood samples. These models have identified specific epigenetic signatures at baseline, before treatment begins, that are linked to treatment responses, including clinical remission and mucosal repair, across various biologic agents.

This breakthrough enables healthcare providers to tailor treatment plans based on these epigenetic markers, greatly improving patient outcomes and moving away from the trial-and-error approach. By leveraging predictive tools, we aim to implement data-driven, personalized therapeutic strategies that enhance treatment efficacy and minimize risks.

Our focus on epigenetics and machine learning marks a significant advancement in precision medicine, allowing clinicians to optimize treatment and reduce the risks associated with delayed effective intervention. With these innovations, HORAIZON is transforming the treatment landscape for inflammatory bowel disease, paving the way towards a future where healthcare is truly individualized and predictive.

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